HIV research back on track

Almost hidden by acres of UK media coverage of the (at times hysterical) debate about hybrid human animal embryo research, I was interested to spot a small item about HIV vaccine research. It was in the Financial Times this morning, based on a Reuters report. Last month we blogged about leading scientists calling for HIV vaccine research to go back to basics, including animal research. Now, according to Reuters, the US government has acted:

The US government has announced a major overhaul of its effort to produce an AIDS vaccine, stressing a return to basic scientific research after the failure of a key clinical trial last year.

Government officials at a summit with AIDS scientists pledged to prioritise spending on lab work and animal tests rather than expensive, and thus far disappointing, large-scale vaccine trials on humans. ‘We need to turn the knob in the direction of discovery. That is unambiguous,’ said Dr Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, who convened the meeting outside of Washington.

Let’s hope, for the sake of patients, that sense will also prevail in our current scientific/political/ethical/religious/media preoccupation with hybrid embryo research.

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  1. The NIAID summit on the future of HIV vaccine research was prompted by the failure of several HIV-prevention candidates in clinical trials, notably the STEP vaccine study which ended prematurely last year. This study showed a greater risk of infection to those receiving vaccine than those receiving placebo. Although the same effect has been observed in some SIV vaccines, (SIV being the monkey equivalent of HIV), it was not seen in the monkey equivalent of the vaccine used in the STEP trial. However, this SIV vaccine showed no ability to prevent or control infection in monkeys. The failure of the STEP vaccine cannot be placed at the door of misleading monkey experiments - as Ronald Desrosiers has pointed out. He was never optimistic about the prospects of the STEP study.

    Posted by Toots / April 04, 2008 | Friday | 01:39 PM |
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